Beta Endorphins & Wellness

Beta Endorphins, the endogenous opiates, have been the subject of
many recent publications. Beta Endorphin levels have positive effects, particularly on mood and behaviour. Endorphins increased after aerobic exercise, massage, and sex.
Beta endorphin is composed of the 31 amino acids and influence the sensation of pain and well being. It has been shown also to Control the craving for chocolate and and potentially addictive substances.
Endorphins also Control feelings of stress and frustration.
It Regulate the production of growth and sex hormones and Reduce symptoms associated with eating disorders.
The human body produces at least 20 different endorphins with possible benefits and uses that researchers are investigating. Beta endorphin appears to be the endorphin that seems to have the strongest affect on the brain and body during exercise; it is one kind of peptide hormone that is formed mainly by Tyrosine, an amino acid. The molecular structure is very similar to morphine but with different chemical properties.

While many people are vaguely aware that the blissful feelings one experiences after sex may be endorphin related, few are aware that endorphins are naturally produced by a wide range of activities like meditation, deep breathing, ribald laughter, eating spicy food, or receiving acupuncture treatments or chiropractic adjustments. Fewer still know that endorphins are actually good for health, and can play a role in helping drug and alcohol abusers overcome their addiction. Lets explore some of the dynamics of endorphins and how they affect our daily lives.

Although more research needs to be done, endorphins are believed to produce four key effects on the bodymind: they enhance the immune system, they relieve pain, they reduce stress, and postpone the aging process. Scientists also have found that beta-endorphins can activate human NK (Natural Killer) cells and boost the immune system against diseases and kill cancer cells. In contrast to short-intensity workouts like sprinting or weightlifting, prolonged, continuous exercise like running, long-distance swimming, aerobics, cycling or cross-country skiing appears to contribute to an increased production and release of endorphins. This results in a sense of euphoria that has been popularly labeled the “runner’s high.”

Dr. George Grant participated in early research[1981] in isolating Beta Endorphins in neonates at the faculty pharmacy, University of Sask. and the neonatal unit at the faculty of Medicine, University of Sask. with Dr. Wayne Hindmarsh, assistant dean of Pharmacy at Univrsity of Sask. currently Dean of Pharmacy at the University of Toronto and Dr. Sankaran, Facutly of Medicine.

Dr. K. Wayne Hindmarsh, PhD; Dr. K.Sankaran,t MB FRCPC FAAP

CAN MED ASSOC J, VOL. 132, FEBRUARY 15, 1985

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Jul 30, 2015 – Citation: Grant G (2015) Beta Endorphins & Wellness. … different endorphins with possible benefits and uses that researchers are investigating.

Mediation of βendorphin in exercise‐induced improvement in insulin resistance in obese Zucker rats

CF Su, YY Chang, HH Pai, IM Liu… – … research and reviews, 2005 – Wiley Online LibraryBackground Aerobic exercise including treadmill running has long been used to
successfully treat and/or prevent insulin resistance and type‐2 diabetes. Increase of plasma
βendorphin is observed with exercise. The present study was designed to clarify the role of …Cited by 47Related articlesAll 8 versions

Infusion of βendorphin improves insulin resistance in fructose-fed rats

CF Su, YY Chang, HH Pai, IM Liu… – Hormone and …, 2004 – thieme-connect.comIn an attempt to probe the effect of βendorphin on insulin resistance, we used Wistar rats
that were fed fructose-rich chow to induce insulin resistanceInsulin action on glucose
disposal rate (GDR) was measured using the hyperinsulinemic euglycemic clamp …Cited by 31Related articlesAll 4 versions[PDF] hindawi.com

Myricetin ameliorates defective post-receptor insulin signaling via βendorphin signaling in the skeletal muscles of fructose-fed rats

TF Tzeng, SS Liou, IM Liu – Evidence-Based Complementary and …, 2011 – hindawi.com… View at PubMed · View at Scopus; CF Su, YY Chang, HH Pai, IM Liu, CY Lo, and JT Cheng,
“Mediation of betaendorphin in exercise … C.-F. Su, Y.-Y. Chang, H.-H. Pai, I.-M. Liu, C.-Y. Lo, and
J.-T. Cheng, “Infusion of βendorphin improves insulinresistance in fructose-fed …Cited by 36Related articlesAll 13 versions

Metformin increases insulin sensitivity and plasma βendorphin in human subjects

HY Ou, JT Cheng, EH Yu, TJ Wu – Hormone and metabolic …, 2006 – thieme-connect.com… Y Y, Pai H H, Liu I M, Lo C Y, Cheng J T. Infusion of βendorphin improves insulin … Y Y, Pai H H,
Liu I M, Lo C Y, Cheng J T. Mediation of betaendorphin in exercise … Rudenski A S, Naylor B A,
Treacher D F, Turner R C. Homeostasis model assessment: insulinresistance and betaCited by 36Related articlesAll 6 versions

Insulin, C-peptide, androgens, and betaendorphin response to oral glucose in patients with polycystic ovary syndrome

G Tropeano, A Lucisano, I Liberale… – The Journal of …, 1994 – academic.oup.com… based on the observation of elevated fasting and glucose-stimulated P-endorphin (PEP) levels …
a glucose challenge would allow us to document and quantitate insulinresistance and that …
associated with an increase in androgens and PEP levels in insulinresistant women with …Cited by 39Related articlesAll 7 versions

Reduction of hyperinsulinemia and insulin resistance by opiate receptor blockade in the polycystic ovary syndrome with acanthosis nigricans

JR GIVENS, BR KURTZ, AE KITABCHI… – The Journal of …, 1987 – academic.oup.com… (8) sug- gested that the hyperglycemic action of endorphins is mediated at … J Clin Endocrinol Metab
52:592 8. Feldman M, Riser RS, Unger RH, Li CH 1983 Betaendorphin and the … Aleem FA,
Mclntosh T 1984 Elevated plasma levels of/8-endorphin in a group of women with …Cited by 48Related articlesAll 5 versions[HTML] fertstert.org

Insulin resistance influences central opioid activity in polycystic ovary syndrome

A Berent-Spillson, T LoveR Pop-Busui, MF Sowers… – Fertility and sterility, 2011 – Elsevier… emission tomography. glucose regulation. μ-opioid receptors. neuroimaging. βendorphins. PCOS.
insulin … are expressed in proopiomelanocortin-containing neurons, the precursor of βendorphin
RC TurnerHomeostasis model assessment: insulinresistance and beta-cell function …Cited by 13Related articlesAll 16 versions

Opioid μ-receptors as new target for insulin resistance

KC Cheng, A Asakawa, YX Li, IM Liu, H Amitani… – Pharmacology & …, 2013 – Elsevier… of insulinresistance was associated with an elevation of circulating βendorphin to ameliorate
the post-receptor insulin signaling cascade, including downstream effectors of the
phosphatidylinositol 3-kinase (PI3-kinase) signaling pathway. In insulinresistant rats, Loperamide …Cited by 17Related articlesAll 8 versions

Activation of I2-imidazoline receptors by agmatine improved insulin sensitivity through two mechanisms in type-2 diabetic rats

CH Su, IM Liu, HH Chung, JT Cheng – Neuroscience letters, 2009 – Elsevier… oxidase and the I 3 -imidazoline receptor which regulates insulin secretion from pancreatic beta
cells [9 … Otherwise, it has been shown that βendorphin possess the ability to reverse the impaired
insulin-stimulated glucose disposal in rats with insulinresistance [16], [17] …Cited by 45Related articlesAll 8 versi

Body fat distribution, insulin resistance, and metabolic diseases

PER Björntorp – Nutrition, 1997 – Elsevier… P BjörntorpFatty acids, hyperinsulinemia and insulinresistance: which comes first … Vague, P Vague,
J Boyer, MC CloixAnthropometry of obesity, diabetes, adrenal and beta-cell functions … R Pasquali,
F Casimirri, S Cantobelli, et al.βendorphin response to exogenous corticotropin …Cited by 578Related articlesAll 8 versi

We measured CSF levels of the opioid peptides β-endorphin and β-lipotropin in patients with Alzheimer’s disease, multi-infarct dementia and controls. In both dementia moups, the mean concentration of β-endomhin was significantly lower than in controls. The mean β-lipotropin levels did not differ significantly in the two groups. The low CSF β-endorphin level may relate generally to dementia.

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