Research Proposal for Examining Tissue Hypoxia as related to Fibromyalgia/ Chronic Fatigue Syndrome (Myalgic Encephalomyelitis)/ Multiple Chemical Sensitivities & Evaluating 2,3DPG as a Biochemical marker using double blind clinical trials

Brief History
A team of medical doctors, Naturopaths, Chiropractors, Complimentary/Alternative Therapists and Research Scientists have completed a preliminary investigation on the relationship between tissue hypoxia and FM/CFS/MCS and approximately 50 clients were given a high absorption multivitamins/minerals/Bioflavonoid and over 90% have reported higher energy, less muscle/joint pain and better sleep during 3,6 and 9 months period supported by a blood test and a questionnaire.

Possible Causes
We believe that tissue hypoxia, high 2,3 DPG (2,3-diphosphoglycerate), high substance P (pain neurotransmitter), low serotonin, low norepinephrine, high cortisol, low HDL, high LDL, high VLDL, high Homocystein are the key factors in the pathophysiology of FM/CFS/MCS. Medications that have been tried in raising serotonin and norepinephrine neurotransmitter levels have limited success (Elavil, Effexor, Paxil, Xanax, Sezone and Prozac)

None of the NSAID’s like Aspirin and Tylenol were effective in relieving pain. The supplement program used over 3,6 and 9 months period produced remarkable reduction of musculoskeletal pain, increased energy and better sleep for over 90% of patients.

Other Related Research Projects: ADD/ADHD/Heart Disease/High Cholesterol/Weight Management/Depression/Asthma/Allergies.... Currently we are doing a pilot study using Natural Supplements + Antioxidants for 9 months and upon completion, double blind randomized clinical trials using 2 active ingredients as well as a placebo will be completed as soon as we complete the pilot study and obtain funding for our research project.

References

• International Pain Conference, London, England, March 2000. Drs. George Grant, and Alan Drizen The use of IPM/Diclofenac in Pain Management.
• Natural Remedies & Supplement, Drs. Grant, Ko, Levi, Mekhail, Nakla, and Pettel .
• Journal of Investigative Medicine Dr. Folts, Univ. of Wisconsin Medical School
• American College Of Cardiology 47th and 48th Annual Convention.

Research Associates

• Dr. George Grant, M.Sc., M.Ed., Ed.D., C.Chem., R.M. Principal Investigator, Biochemist/Toxicologist/Microbiologist/Nutritionist, Richmond Hill, ON.
• Dr. Haword Awad, M.D., FRCP, Private Practice, Oakville, ON.
• Dr. Hans Scwartz, DMD
• Dr. Dilkhush Panjwani, M.D., MRCPsych, FRCP, Staff Psychiatrist, Toronto, ON.
• Dr. James Wylie, M.D. Private Practice, Brampton, ON.
• Dr. Yussaf Ali, M.D., Assistant Professor, University of Rochester, NY
• Dilnaz Panjawani, Clinical Researcher, Mount Sinai Hospital, Toronto, ON
• Dr. Elvis Ali, B.Sc., N.D., Private Practice, Toronto, ON
• Dr. Robert Cohen, D.C., Chiropractor, Mississauga
• Dr. Veronica Kekosz-Paul, MD, FRCPC, Consultant: Physical Medicine & Rehabilitation.